The HLA (human leucocyte antigen) system encodes the major histocompatibility complex (MHC) proteins in humans, and is closely related to the body's immune system. The HLA gene complex is located on a 3.6 Mb region within chromosome 6p21. They are the most polymorphic gene family found in the human genome, with more than 10,000 different HLA alleles reported to date, thus the capacity to mount an immune response can be remarkably different between individuals within a cohort selected from a single population.

HLA genes have been strongly implicated in transplant rejection, autoimmune disease, vaccine pharmacogenomics, cancer, and infectious diseases. HLA genotyping is the identification of the HLA class I and class II gene polymorphisms for individuals, which is indispensable for transplant matching and disease association studies.

Capitabio specializes in cutting-edge HLA Typing Kits, designed for the precise human leukocyte antigen test. Our comprehensive solutions cater to both research and clinical applications, ensuring high accuracy in every HLA typing test. Trust Capitabio for reliable and efficient HLA analysis, supporting your scientific and medical endeavors with unparalleled precision.

HLA Typing Meaning

HLA typing refers to the process of determining the specific alleles present in an individual's human leukocyte antigen (HLA) genes. The HLA system is a group of genes located on chromosome 6 that encode proteins involved in the immune system's recognition and response to foreign substances, such as pathogens or transplanted tissues or organs.

HLA typing is performed through molecular methods, often utilizing techniques like Polymerase Chain Reaction (PCR) and DNA sequencing. These methods analyze specific regions within the HLA genes and identify the alleles present in an individual's genetic makeup.

HLA typing is important for several medical and scientific applications, including organ and tissue transplantation, hematopoietic stem cell transplantation (bone marrow transplantation), predicting disease susceptibility, understanding immune responses, forensic investigations, and population genetics studies.

Matching HLA types between a donor and recipient is crucial in transplantation to minimize the risk of rejection and improve the compatibility of transplanted tissues or organs. In disease research, certain HLA alleles are associated with an increased or decreased risk of developing certain conditions, aiding in understanding genetic factors and designing targeted treatment strategies.

Overall, HLA typing plays a vital role in various fields by providing valuable information about an individual's immune system and genetic compatibility, contributing to personalized medicine and scientific advancements.

CapitalBio HLA Typing Kits

CapitalBio offers HLA typing kits, also known as HLA genotyping kit. These HLA genotyping kits are used in medical laboratories to identify a patient's Human Leukocyte Antigen (HLA) type. HLA molecules play a crucial role in immune response and tissue compatibility. CapitalBio's HLA typing kit likely contain reagents and instructions for extracting DNA, amplifying specific HLA gene regions, and analyzing the genetic variations to determine the patient's unique HLA type. This information is vital for organ transplantation matching, as well as understanding a patient's susceptibility to certain autoimmune diseases.

Capitalbio technology co ltd (abbreviated “CapitalBio”) is the industrialization platform of the CapitalBio Corporation and the Beijing National Engineering Research Center for Biochips.

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