Chromatography System

Hanbon chromatographic equipment has reliable performance and flexible configuration, and can provide Bio-Lab® laboratory chromatography system, Bio-Pro® pilot&process chromatography system, etc.

As a trusted chromatography equipment manufacturer, Hanbon ensures its systems deliver high accuracy, efficiency, and reliability, making them suitable for both small-scale laboratory work and large-scale biopharmaceutical production.

Types of Hanbon Chromatography System

Bio-Lab® Laboratory Chromatography System

Bio-Lab is available in three models: Bio-lab30, Bio-Lab100 and Bio-Lab300, to meet the needs of different users.

Bio-Pro® Pilot & Process Chromatography System

Based on the requirements of ASME BPE and GMP, the system adopts an integrated module design which can realize multi configura tions according to the specific requirements of customers.

Common Principles Of Process Scale-Up: Linear Scale-Up

Linear scale-up is the most common principle used in process scale-up. By linear scale-up, we mean that we can obtain almost uniform chromatographic results from laboratory scale to pilot results or industrial production level. The core idea is to keep the column height and linear flow rate constant and only scale up the column diameter and volume flow rate. A fixed column height and linear flow rate theoretically ensures the same retention time, the number of CVs used in chromatography and the number of CVs of the eluted sample, maximizing the same purification results. Theoretically, this linear scale-up of the purification separation behavior should be very similar, thus ensuring a successful scale-up of the chromatographic process. However, some additional factors need to be considered, including a decrease in column tube support (increased pressure drop), column efficiency/column bed instability, sample diffusion (peak spreading), and dead volume of the system and tubing.

Conversion Of Linear Flow Rates (Cm/H) To Volumetric (Ml/Min) Flow Rates

When comparing results from columns of different sizes, it is convenient to express the flow rate as a linear flow rate (cm/h). However, flow rates are often measured as volumetric flow rates (ml/min). In order to convert between linear and volumetric flow rates, one of the following equations can be used .