The study of mitophagy is currently a hot research topic in biology. The mitochondria-specific localization fluorescent probe (HBAD-Mito-dsred) developed independently by HANBIO can accurately localize and label mitochondria, which can be used in combination with HANBIO's exclusive dual-fluorescent LC3 cellular autophagy adenovirus, it can accurately track the dynamic process of mitophagy in real time. Mitophagy is the process by which cells selectively remove mitochondria through the mechanism of autophagy. Selective removal of damaged or functionally incomplete mitochondria is critical for the functional integrity of the entire mitochondrial network and for cell survival. Abnormalities in mitophagy are closely related to many diseases, so it is biologically important to study the specific molecular mechanisms as well as the physiological significance of mitophagy.

Signaling Pathway of Mitophagy

1. Pink/Parkin pathway

2. Bnip3/Nix pathway

3. FUNDC1 pathway

Mitophagy pathway: Pink1/Parkin OR Bnip3/Nix

Abnormalities in mitophagy are closely related to many diseases, so it is biologically important to study the specific molecular mechanisms of mitophagy as well as its physiological significance. HANBIO has an experienced mitophagy research team to provide you with a research program and tools for mitophagy.